Non-rheumatic valve diseases

DOID EFO MESH SNOMED PheWeb

I9_NONRHEVALV

heart valve disease: A disease involving the cardial valve.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I34, I35, I36, I37

Hospital discharge: ICD-9 424

Hospital discharge: ICD-8 39[4-6]|424

Hospital discharge: excluded ICD-8 4249|3940|3950|3960|3970

Cause of death: ICD-10 I34, I35, I36, I37

Cause of death: ICD-9 424

Cause of death: ICD-8 39[4-6]|424

Cause of death: excluded ICD-8 4249|3940|3950|3960|3970

16333

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

16307

Check minimum number of events None

16307

Include endpoints None

16307

I9_NONRHEVALV

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Non-rheumatic valve diseases based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	15799	6841	8958
Unadjusted prevalence (%)	5.12	3.94	6.63
Mean age at first event (years)	65.75	65.38	66.04

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.65 [3.18, 4.19]	1.8e-74	2903
15 years	0.01	1.77 [1.56, 2.02]	3.3e-18	1153
5 years	0.00	3.47 [3.10, 3.87]	<1e-100	950
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases
GWS hits: 2

Survival analyses between endpoints

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Plot

before Non-rheumatic valve diseases
after Non-rheumatic valve diseases

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Non-rheumatic valve diseases

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