Non-rheumatic valve diseases

I9_NONRHEVALV

heart valve disease: A disease involving the cardial valve.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 I34, I35, I36, I37
Hospital discharge: ICD-9 424
Hospital discharge: ICD-8 39[4-6]|424
Hospital discharge: excluded ICD-8 4249|3940|3950|3960|3970
Cause of death: ICD-10 I34, I35, I36, I37
Cause of death: ICD-9 424
Cause of death: ICD-8 39[4-6]|424
Cause of death: excluded ICD-8 4249|3940|3950|3960|3970

16333

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

16307

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Check minimum number of events None

16307

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Include endpoints None

16307

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I9_NONRHEVALV

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 15799 6841 8958
Unadjusted prevalence (%) 5.12 3.94 6.63
Mean age at first event (years) 65.75 65.38 66.04

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.65 [3.18, 4.19] 1.8e-74 2903
15 years 0.01 1.77 [1.56, 2.02] 3.3e-18 1153
5 years 0.00 3.47 [3.10, 3.87] <1e-100 950
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases
GWS hits: 2

Survival analyses between endpoints

Plot

before Non-rheumatic valve diseases
after Non-rheumatic valve diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-rheumatic valve diseases