Aortic valve malfunction, age under 60 years

PheWeb

I9_AORTVALV_EARLY

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I35.0, I35.1, I35.2, I35.8

Hospital discharge: ICD-9 4242[A-C]

Cause of death: ICD-10 I35.0, I35.1, I35.2, I35.8

Cause of death: ICD-9 4242[A-C]

10810

Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE < 60

Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9

2149

Check minimum number of events None

2149

Include endpoints None

2149

I9_AORTVALV_EARLY

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Aortic valve malfunction, age under 60 years based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2085	750	1335
Unadjusted prevalence (%)	0.68	0.43	0.99
Mean age at first event (years)	49.13	48.52	49.47

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.97 [1.15, 3.39]	1.4e-2	133
15 years	0.01	1.81 [1.10, 2.96]	1.9e-2	73
5 years	0.00	3.32 [1.90, 5.79]	2.4e-5	26
1 year	0.00	8.25 [4.03, 16.88]	7.5e-9	11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_AORTVALV_EARLY – Aortic valve malfunction, age under 60 years
GWS hits:

Survival analyses between endpoints

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Plot

before Aortic valve malfunction, age under 60 years
after Aortic valve malfunction, age under 60 years

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Table

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Drugs most likely to be purchased after Aortic valve malfunction, age under 60 years

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