Diseases of the circulatory system

PheWeb

IX_CIRCULATORY

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I00-I99

Hospital discharge: ICD-9 39|4[0-5]

Hospital discharge: ICD-8 39|4[0-5]

Cause of death: ICD-10 I00-I99

Cause of death: ICD-9 39|4[0-5]

Cause of death: ICD-8 39|4[0-5]

158538

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

158538

Check minimum number of events None

158538

Include endpoints None

158538

IX_CIRCULATORY

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diseases of the circulatory system based on the number of shared cases.

Broader endpoints:

Any ICDMAIN event in hilmo or causes of death

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	153728	77872	75856
Unadjusted prevalence (%)	49.82	44.88	56.18
Mean age at first event (years)	53.58	51.20	56.02

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	5.55 [5.20, 5.92]	<1e-100	23214
15 years	0.01	3.52 [3.25, 3.80]	<1e-100	10442
5 years	0.00	5.32 [4.84, 5.84]	<1e-100	4681
1 year	0.00	26.17 [21.85, 31.35]	<1e-100	3803

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: IX_CIRCULATORY – Diseases of the circulatory system
GWS hits:

Survival analyses between endpoints

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Plot

before Diseases of the circulatory system
after Diseases of the circulatory system

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Table

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Drugs most likely to be purchased after Diseases of the circulatory system

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