Epilepsy

G6_EPLEPSY

epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G40
Hospital discharge: ICD-9 345
Hospital discharge: ICD-8 345
Hospital discharge: excluded ICD-9 3452|3453
Hospital discharge: excluded ICD-8 34520
Cause of death: ICD-10 G40
Cause of death: ICD-9 345
Cause of death: ICD-8 345
Cause of death: excluded ICD-9 3452|3453
Cause of death: excluded ICD-8 34520
KELA reimbursements: KELA codes 111

8823

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

8814

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Check minimum number of events None

8814

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Include endpoints None

8814

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G6_EPLEPSY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47

Summary Statistics

Key figures

All Female Male
Number of individuals 8523 4214 4309
Unadjusted prevalence (%) 2.76 2.43 3.19
Mean age at first event (years) 43.20 39.35 46.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.65 [2.69, 4.95] 7.0e-17 1526
15 years 0.01 1.79 [1.39, 2.30] 6.0e-6 492
5 years 0.01 4.99 [4.16, 5.97] 3.1e-68 439
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_EPLEPSY – Epilepsy
GWS hits: 0

Survival analyses between endpoints

Plot

before Epilepsy
after Epilepsy

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