Generalized epilepsy

DOID EFO MESH SNOMED PheWeb

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G40.0, G40.1

Hospital discharge: ICD-9 345[0-1]

Hospital discharge: ICD-8 345[0-1]

Hospital discharge: excluded ICD-8 34511

Cause of death: ICD-10 G40.0, G40.1

Cause of death: ICD-9 345[0-1]

Cause of death: ICD-8 345[0-1]

Cause of death: excluded ICD-8 34511

2725

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2718

Check minimum number of events None

2718

Include endpoints None

2718

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Generalized epilepsy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2632	1377	1255
Unadjusted prevalence (%)	0.85	0.79	0.93
Mean age at first event (years)	41.61	38.88	44.59

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.05 [1.94, 8.46]	2.0e-4	415
15 years	0.01	1.93 [1.11, 3.33]	1.9e-2	140
5 years	0.01	5.59 [3.88, 8.06]	2.7e-20	131
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE – Generalized epilepsy
GWS hits: 0

Survival analyses between endpoints

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Plot

before Generalized epilepsy
after Generalized epilepsy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Generalized epilepsy

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