Diseases of the nervous system

PheWeb

VI_NERVOUS

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 B02.2+, G00-G99, G71.10#, G71.11, G71.12, G71.13, G71.14, G71.15, G71.18

Hospital discharge: ICD-9 3[2-5]

Hospital discharge: ICD-8 3[2-5]

Cause of death: ICD-10 B02.2+, G00-G99, G71.10#, G71.11, G71.12, G71.13, G71.14, G71.15, G71.18

Cause of death: ICD-9 3[2-5]

Cause of death: ICD-8 3[2-5]

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

108668

VI_NERVOUS

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diseases of the nervous system based on the number of shared cases.

Broader endpoints:

Any ICDMAIN event in hilmo or causes of death

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	105173	58064	47109
Unadjusted prevalence (%)	34.09	33.46	34.89
Mean age at first event (years)	52.24	49.86	55.18

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.62 [2.40, 2.85]	<1e-100	11561
15 years	0.01	1.57 [1.44, 1.70]	9.4e-26	4765
5 years	0.00	3.17 [2.94, 3.41]	<1e-100	3385
1 year	0.00	8.93 [8.03, 9.93]	<1e-100	2039

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: VI_NERVOUS – Diseases of the nervous system
GWS hits:

Survival analyses between endpoints

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Plot

before Diseases of the nervous system
after Diseases of the nervous system

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Table

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Drugs most likely to be purchased after Diseases of the nervous system

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