Migraine

G6_MIGRAINE

migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G43

Hospital discharge: ICD-9 346

Hospital discharge: ICD-8 346

Hospital discharge: excluded ICD-8 34601

Cause of death: ICD-10 G43

Cause of death: ICD-9 346

Cause of death: ICD-8 346

Cause of death: excluded ICD-8 34601

13961

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13947

Check minimum number of events None

13947

Include endpoints

G6_MIGRAINE_NO_AURA

G6_MIGRAINE_WITH_AURA

13947

G6_MIGRAINE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G40-G47

Name in latin Hemicrania

Similar endpoints

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List of similar endpoints to Migraine based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	13465	11057	2408
Unadjusted prevalence (%)	4.36	6.37	1.78
Mean age at first event (years)	40.39	40.20	41.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.08 [0.79, 1.49]	6.2e-1	265
15 years	0.01	0.91 [0.67, 1.24]	5.4e-1	144
5 years	0.00	1.00 [0.68, 1.48]	9.9e-1	38
1 year	0.00	1.62 [0.86, 3.06]	1.4e-1	11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_MIGRAINE – Migraine
GWS hits: 4

Survival analyses between endpoints

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Plot

before Migraine
after Migraine

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Table

Loading survival analyses table

Drugs most likely to be purchased after Migraine

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