Generalized epilepsy, mode (most common among epilepsy diagnosis)

DOID EFO MESH SNOMED PheWeb

GE_MODE

generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G40.0, G40.1

Hospital discharge: ICD-9 %345[0-1]

Hospital discharge: ICD-8 %345[0-1]

Hospital discharge: excluded ICD-8 34511

Cause of death: ICD-10 G40.0, G40.1

Cause of death: ICD-9 %345[0-1]

Cause of death: ICD-8 %345[0-1]

Cause of death: excluded ICD-8 34511

8151

Check pre-conditions, main-only, mode, ICD version

Check mode of ICD-10 codes: %345[0-1], %G40[0-1]

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1761

Check minimum number of events None

1761

Include endpoints None

1761

GE_MODE

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Generalized epilepsy, mode (most common among epilepsy diagnosis) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2632	1377	1255
Unadjusted prevalence (%)	0.85	0.79	0.93
Mean age at first event (years)	41.61	38.88	44.59

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.86 [1.65, 4.97]	1.8e-4	415
15 years	0.01	1.60 [1.00, 2.56]	5.1e-2	140
5 years	0.01	5.19 [3.73, 7.21]	1.3e-22	131
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: GE_MODE – Generalized epilepsy, mode (most common among epilepsy diagnosis)
GWS hits: 0

Survival analyses between endpoints

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Plot

before Generalized epilepsy, mode (most common among epilepsy diagnosis)
after Generalized epilepsy, mode (most common among epilepsy diagnosis)

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Table

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Drugs most likely to be purchased after Generalized epilepsy, mode (most common among epilepsy diagnosis)

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