Metabolic disorders


metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E70-E90
Cause of death: ICD-10 E70-E90


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 39582 19061 20521
Unadjusted prevalence (%) 12.83 10.98 15.20
Mean age at first event (years) 62.29 61.60 62.93


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.48 [3.08, 3.93] 3.1e-90 5612
15 years 0.01 1.62 [1.44, 1.82] 1.2e-15 2012
5 years 0.00 3.69 [3.36, 4.06] <1e-100 1858
1 year 0.00 14.06 [12.54, 15.77] <1e-100 1522

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 21

Survival analyses between endpoints


before Metabolic disorders
after Metabolic disorders

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Drugs most likely to be purchased after Metabolic disorders