Metabolic disorders

E4_METABOLIA

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E70-E90

Cause of death: ICD-10 E70-E90

54445

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

39920

Check minimum number of events None

39920

Include endpoints

E4_AROMAMINO

E4_BRANCHAMINOFATAC

E4_AMINO

E4_LACTOSEINT

E4_CARBO

E4_SPHINGOLIP

E4_GLYCOSAMINOGLYC

E4_GLYCOPROT

E4_LIPOPROT

E4_PURINEPYRI

E4_PORBILIR

E4_MINERAL_MET

E4_CYSTFIBRO

E4_AMYLOIDOSIS

E4_VOLUME

E4_FLUIDELECTRO

E4_METABO

40919

E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Metabolic disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

39582

19061

20521

Unadjusted prevalence (%)

12.83

10.98

15.20

Mean age at first event (years)

62.29

61.60

62.93

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.48 [3.08, 3.93]	3.1e-90	5612
15 years	0.01	1.62 [1.44, 1.82]	1.2e-15	2012
5 years	0.00	3.69 [3.36, 4.06]	<1e-100	1858
1 year	0.00	14.06 [12.54, 15.77]	<1e-100	1522

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 21

Survival analyses between endpoints

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Plot

before Metabolic disorders
after Metabolic disorders

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Metabolic disorders

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