Other metabolic disorders

E4_METABO

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E88

Cause of death: ICD-10 E88

6944

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

247

Check minimum number of events None

247

Include endpoints

E4_PLASMAPROT

E4_LIPODYST

E4_LIPOMATOSIS

E4_TUMOURLYSISSDR

E4_METABONAS

E4_ENDOMETPOSTOP

E4_METABINOTH

2776

E4_METABO

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E70-E90

Name in latin Aliae morbositates metabolicae

Similar endpoints

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List of similar endpoints to Other metabolic disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2662	2080	582
Unadjusted prevalence (%)	0.86	1.20	0.43
Mean age at first event (years)	52.13	51.84	53.16

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.25 [2.76, 6.52]	4.2e-11	139
15 years	0.01	2.07 [1.36, 3.16]	7.2e-4	55
5 years	0.00	4.40 [2.64, 7.34]	1.3e-8	47
1 year	0.00	10.61 [6.07, 18.53]	1.1e-16	22

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABO – Other metabolic disorders
GWS hits: 3

Survival analyses between endpoints

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Plot

before Other metabolic disorders
after Other metabolic disorders

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Table

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Drugs most likely to be purchased after Other metabolic disorders

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