Other metabolic disorders


metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E88
Cause of death: ICD-10 E88


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


diagram downward connector

Check minimum number of events None


diagram downward connector

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Aliae morbositates metabolicae

Similar endpoints

List of similar endpoints to Other metabolic disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 2662 2080 582
Unadjusted prevalence (%) 0.86 1.20 0.43
Mean age at first event (years) 52.13 51.84 53.16


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 4.25 [2.76, 6.52] 4.2e-11 139
15 years 0.01 2.07 [1.36, 3.16] 7.2e-4 55
5 years 0.00 4.40 [2.64, 7.34] 1.3e-8 47
1 year 0.00 10.61 [6.07, 18.53] 1.1e-16 22

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_METABO – Other metabolic disorders
GWS hits: 3

Survival analyses between endpoints


before Other metabolic disorders
after Other metabolic disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other metabolic disorders