Familial hypercholesterolemia

PheWeb

E4_FH

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E78.00

Hospital discharge: ICD-9 2720A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E78.00

Cause of death: ICD-9 2720A

Cause of death: ICD-8 $!$

4080

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4080

Check minimum number of events None

4080

Include endpoints None

4080

E4_FH

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF6v3

Similar endpoints

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List of similar endpoints to Familial hypercholesterolemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Familial hypercholesterolemia, with ichemic heart disease

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3964	1656	2308
Unadjusted prevalence (%)	1.28	0.95	1.71
Mean age at first event (years)	63.89	63.98	63.82

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.05 [2.11, 4.42]	3.7e-9	633
15 years	0.01	1.46 [0.98, 2.17]	6.4e-2	275
5 years	0.00	3.42 [2.43, 4.83]	2.0e-12	216
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH – Familial hypercholesterolemia
GWS hits:

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia
after Familial hypercholesterolemia

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Table

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Drugs most likely to be purchased after Familial hypercholesterolemia

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