Lactose intolerance


lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E73
Cause of death: ICD-10 E73


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Include endpoints


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Intolerantia lactosi

Summary Statistics

Key figures

All Female Male
Number of individuals 655 453 202
Unadjusted prevalence (%) 0.21 0.26 0.15
Mean age at first event (years) 38.57 38.31 39.15


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.31 [0.43, 3.96] 6.3e-1 49
15 years 0.01 1.10 [0.43, 2.83] 8.4e-1 27
5 years 0.00 1.66 [0.71, 3.91] 2.4e-1 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_LACTOSEINT – Lactose intolerance
GWS hits: 2

Survival analyses between endpoints


before Lactose intolerance
after Lactose intolerance

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Drugs most likely to be purchased after Lactose intolerance