Type 2 diabetes

E4_DM2

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E11

Cause of death: ICD-10 E11

Medicine purchases: ATC A10B

53463

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

49670

Check minimum number of events

Min. number of events 3

49670

Include endpoints

E4_DM2COMA

E4_DM2KETO

E4_DM2REN

E4_DM2OPTH

E4_DM2NEU

E4_DM2PERIPH

E4_DM2NASCOMP

E4_DM2NOCOMP

50991

E4_DM2

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF3

Parent code in ICD-10 E10-E14

Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Similar endpoints

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List of similar endpoints to Type 2 diabetes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	49303	22142	27161
Unadjusted prevalence (%)	15.98	12.76	20.12
Mean age at first event (years)	58.72	57.62	59.61

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.46 [2.22, 2.72]	2.1e-69	7830
15 years	0.01	1.69 [1.54, 1.85]	1.5e-29	3995
5 years	0.00	2.64 [2.43, 2.87]	<1e-100	1958
1 year	0.00	4.64 [4.09, 5.27]	<1e-100	668

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2 – Type 2 diabetes
GWS hits: 105

Survival analyses between endpoints

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Plot

before Type 2 diabetes
after Type 2 diabetes

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Table

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Drugs most likely to be purchased after Type 2 diabetes

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