Type 2 diabetes with coma

E4_DM2COMA

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E11.00, E11.01, E11.09

Hospital discharge: ICD-9 2502A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E11.00, E11.01, E11.09

Cause of death: ICD-9 2502A

Cause of death: ICD-8 $!$

3912

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3912

Check minimum number of events None

3912

Include endpoints None

3912

E4_DM2COMA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Type 2 diabetes with coma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3784	1444	2340
Unadjusted prevalence (%)	1.23	0.83	1.73
Mean age at first event (years)	63.68	62.81	64.22

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.64 [5.08, 8.67]	8.8e-44	1441
15 years	0.02	2.94 [2.35, 3.67]	2.1e-21	557
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2COMA – Type 2 diabetes with coma
GWS hits: 2

Survival analyses between endpoints

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Plot

before Type 2 diabetes with coma
after Type 2 diabetes with coma

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Type 2 diabetes with coma

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