Type 2 diabetes, strict (exclude DM1)

E4_DM2_STRICT

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not E4_DM1

312402

Filter registries

Medicine purchases: ATC A10B

46234

Check pre-conditions, main-only, mode, ICD version None

42096

Check minimum number of events

Min. number of events 3

42096

Include endpoints

E4_DM2COMA

E4_DM2KETO

E4_DM2REN

E4_DM2OPTH

E4_DM2NEU

E4_DM2PERIPH

E4_DM2NASCOMP

E4_DM2NOCOMP

45819

E4_DM2_STRICT

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Type 2 diabetes, strict (exclude DM1) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	44266	19883	24383
Unadjusted prevalence (%)	14.35	11.46	18.06
Mean age at first event (years)	60.21	59.18	61.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.30 [2.07, 2.55]	4.1e-56	6843
15 years	0.01	1.56 [1.42, 1.71]	5.1e-21	3476
5 years	0.00	2.52 [2.31, 2.74]	1.8e-99	1791
1 year	0.00	4.59 [4.03, 5.22]	<1e-100	628

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2_STRICT – Type 2 diabetes, strict (exclude DM1)
GWS hits: 107

Survival analyses between endpoints

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Plot

before Type 2 diabetes, strict (exclude DM1)
after Type 2 diabetes, strict (exclude DM1)

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Table

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Drugs most likely to be purchased after Type 2 diabetes, strict (exclude DM1)

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