Diabetes mellitus

E4_DIABETES

diabetes mellitus: A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

55495

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E4_DIABETES

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Diabetes mellitus based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 53688 24415 29273
Unadjusted prevalence (%) 17.40 14.07 21.68
Mean age at first event (years) 54.51 52.77 55.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.65 [2.42, 2.91] 6.3e-95 8081
15 years 0.01 1.80 [1.66, 1.95] 9.1e-45 4070
5 years 0.00 2.69 [2.48, 2.90] <1e-100 1974
1 year 0.00 4.72 [4.16, 5.35] <1e-100 683

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DIABETES – Diabetes mellitus
GWS hits: 103

Survival analyses between endpoints

Plot

before Diabetes mellitus
after Diabetes mellitus

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Drugs most likely to be purchased after Diabetes mellitus