Seropositive rheumatoid arthritis


rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries None


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Check pre-conditions, main-only, mode, ICD version None


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Check minimum number of events None


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Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Seropositive rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 7294 5064 2230
Unadjusted prevalence (%) 2.36 2.92 1.65
Mean age at first event (years) 54.25 52.64 57.91


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.33 [1.87, 2.90] 3.6e-14 857
15 years 0.01 1.63 [1.35, 1.98] 5.8e-7 432
5 years 0.00 2.45 [2.05, 2.94] 1.0e-22 202
1 year 0.00 3.37 [2.49, 4.56] 3.5e-15 54

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: RHEUMA_SEROPOS – Seropositive rheumatoid arthritis
GWS hits: 29

Survival analyses between endpoints


before Seropositive rheumatoid arthritis
after Seropositive rheumatoid arthritis

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis