Seropositive rheumatoid arthritis

RHEUMA_SEROPOS

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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RHEUMA_SEROPOS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Seropositive rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 7294 5064 2230
Unadjusted prevalence (%) 2.36 2.92 1.65
Mean age at first event (years) 54.25 52.64 57.91

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.33 [1.87, 2.90] 3.6e-14 857
15 years 0.01 1.63 [1.35, 1.98] 5.8e-7 432
5 years 0.00 2.45 [2.05, 2.94] 1.0e-22 202
1 year 0.00 3.37 [2.49, 4.56] 3.5e-15 54

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS – Seropositive rheumatoid arthritis
GWS hits: 29

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis
after Seropositive rheumatoid arthritis

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis

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