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Other/unspecified seropositiverheumatoid arthritis

DOIDEFOMESHSNOMED PheWeb

RHEUMA_SEROPOS_OTH

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M05.8, M05.9
Hospital discharge: ICD-9 7140A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M05.8, M05.9
Cause of death: ICD-9 7140A
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

7389

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RHEUMA_SEROPOS_OTH

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 7211 5016 2195
Unadjusted prevalence (%) 2.34 2.89 1.63
Mean age at first event (years) 54.26 52.62 58.00

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.35 [1.89, 2.91] 6.4e-15 843
15 years 0.01 1.66 [1.38, 1.99] 8.6e-8 429
5 years 0.00 2.44 [2.03, 2.94] 2.0e-21 198
1 year 0.00 3.26 [2.39, 4.45] 9.6e-14 51

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositiverheumatoid arthritis
GWS hits: 23

Survival analyses between endpoints

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Plot

before Other/unspecified seropositiverheumatoid arthritis
after Other/unspecified seropositiverheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other/unspecified seropositiverheumatoid arthritis

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