Rheumatoid arthritis

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M05, M06

Hospital discharge: ICD-9 7140A|7140B|7241|7142

Hospital discharge: ICD-8 712[1-3]

Cause of death: ICD-10 M05, M06

Cause of death: ICD-9 7140A|7140B|7241|7142

Cause of death: ICD-8 712[1-3]

13229

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

10117

Check minimum number of events None

10117

Include endpoints None

10117

M13_RHEUMA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9855	6733	3122
Unadjusted prevalence (%)	3.19	3.88	2.31
Mean age at first event (years)	51.82	50.20	55.32

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.91 [1.57, 2.32]	1.1e-10	1095
15 years	0.01	1.31 [1.10, 1.56]	2.8e-3	535
5 years	0.00	2.14 [1.81, 2.53]	7.0e-19	254
1 year	0.00	3.22 [2.47, 4.19]	7.2e-18	73

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 19

Survival analyses between endpoints

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Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

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Table

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Drugs most likely to be purchased after Rheumatoid arthritis

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