Rheumatoid arthritis

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

13229

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

10117

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Check minimum number of events None

10117

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Include endpoints None

10117

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M13_RHEUMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 9855 6733 3122
Unadjusted prevalence (%) 3.19 3.88 2.31
Mean age at first event (years) 51.82 50.20 55.32

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.91 [1.57, 2.32] 1.1e-10 1095
15 years 0.01 1.31 [1.10, 1.56] 2.8e-3 535
5 years 0.00 2.14 [1.81, 2.53] 7.0e-19 254
1 year 0.00 3.22 [2.47, 4.19] 7.2e-18 73

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 19

Survival analyses between endpoints

Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

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Drugs most likely to be purchased after Rheumatoid arthritis