Seronegative rheumatoid arthritis

RHEUMA_SERONEG

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M06.0

Hospital discharge: ICD-9 7140B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M06.0

Cause of death: ICD-9 7140B

Cause of death: ICD-8 $!$

3146

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3146

Check minimum number of events None

3146

Include endpoints None

3146

RHEUMA_SERONEG

Extra metadata

First used in FinnGen datafreeze DF3

Parent code in ICD-10 M06

Name in latin Arthritis rheumatoides seronegativa

Similar endpoints

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List of similar endpoints to Seronegative rheumatoid arthritis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3073	2200	873
Unadjusted prevalence (%)	1.00	1.27	0.65
Mean age at first event (years)	53.37	52.02	56.78

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.09 [0.74, 1.60]	6.5e-1	238
15 years	0.01	0.87 [0.62, 1.23]	4.3e-1	123
5 years	0.00	1.39 [0.98, 1.97]	6.9e-2	51
1 year	0.00	2.22 [1.27, 3.87]	5.2e-3	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

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Table

Loading survival analyses table

Drugs most likely to be purchased after Seronegative rheumatoid arthritis

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