Seronegative rheumatoid arthritis


rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

Key figures

All Female Male
Number of individuals 3073 2200 873
Unadjusted prevalence (%) 1.00 1.27 0.65
Mean age at first event (years) 53.37 52.02 56.78


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 1.09 [0.74, 1.60] 6.5e-1 238
15 years 0.01 0.87 [0.62, 1.23] 4.3e-1 123
5 years 0.00 1.39 [0.98, 1.97] 6.9e-2 51
1 year 0.00 2.22 [1.27, 3.87] 5.2e-3 15

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 2

Survival analyses between endpoints


before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

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Drugs most likely to be purchased after Seronegative rheumatoid arthritis