Other (seronegative) rheumatoid arthritis, wide

RHEUMA_OTHER_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M06

Hospital discharge: ICD-9 7140B|7148|7142

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M06

Cause of death: ICD-9 7140B|7148|7142

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

4919

RHEUMA_OTHER_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M05-M14

Name in latin Alia arthritis rheumatoides

Similar endpoints

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List of similar endpoints to Other (seronegative) rheumatoid arthritis, wide based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4795	3307	1488
Unadjusted prevalence (%)	1.55	1.91	1.10
Mean age at first event (years)	54.74	53.07	58.45

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.41 [1.50, 3.86]	2.8e-4	531
15 years	0.01	1.35 [0.82, 2.20]	2.4e-1	230
5 years	0.00	2.88 [2.08, 3.98]	1.8e-10	154
1 year	0.00	7.06 [5.00, 9.97]	1.1e-28	76

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_OTHER_WIDE – Other (seronegative) rheumatoid arthritis, wide
GWS hits: 4

Survival analyses between endpoints

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Plot

before Other (seronegative) rheumatoid arthritis, wide
after Other (seronegative) rheumatoid arthritis, wide

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Table

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Drugs most likely to be purchased after Other (seronegative) rheumatoid arthritis, wide

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