Adult-onset Still disease


adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M06.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M06.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF5
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

Key figures

All Female Male
Number of individuals 81 49 32
Unadjusted prevalence (%) 0.03 0.03 0.02
Mean age at first event (years) 48.11 45.73 51.76


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: STILL_ADULT – Adult-onset Still disease
GWS hits: 4

Survival analyses between endpoints


before Adult-onset Still disease
after Adult-onset Still disease

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Drugs most likely to be purchased after Adult-onset Still disease