Seropositive rheumatoid arthritis, wide

RHEUMA_SEROPOS_WIDE

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M05

Hospital discharge: ICD-9 7140A|7141

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M05

Cause of death: ICD-9 7140A|7141

Cause of death: ICD-8 $!$

7478

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7473

Check minimum number of events None

7473

Include endpoints None

7473

RHEUMA_SEROPOS_WIDE

Extra metadata

First used in FinnGen datafreeze DF3

Parent code in ICD-10 M05-M14

Name in latin Arthritis rheumatoides seropositiva

Similar endpoints

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List of similar endpoints to Seropositive rheumatoid arthritis, wide based on the number of shared cases.

Broader endpoints:

None

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7290	5064	2226
Unadjusted prevalence (%)	2.36	2.92	1.65
Mean age at first event (years)	54.25	52.64	57.91

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.10 [1.74, 2.53]	9.6e-15	855
15 years	0.01	1.48 [1.24, 1.76]	1.0e-5	432
5 years	0.00	2.22 [1.86, 2.66]	2.5e-18	201
1 year	0.00	3.01 [2.22, 4.09]	1.3e-12	54

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 24

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis, wide
after Seropositive rheumatoid arthritis, wide

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Table

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Drugs most likely to be purchased after Seropositive rheumatoid arthritis, wide

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