Other necrotizing vasculopathies (FG)


vasculitis: Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis; see these terms), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease; see these terms), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis; see these terms). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. BehC'et disease, see this term) to relatively minor skin disease.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries None


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Check pre-conditions, main-only, mode, ICD version None


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Check minimum number of events None


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Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Other necrotizing vasculopathies (FG) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 1299 774 525
Unadjusted prevalence (%) 0.42 0.45 0.39
Mean age at first event (years) 60.91 60.19 61.97


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.23 [1.95, 5.33] 4.7e-6 172
15 years 0.01 1.50 [0.98, 2.31] 6.3e-2 68
5 years 0.00 3.14 [2.16, 4.57] 2.0e-9 57
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: NECROVASC_FG – Other necrotizing vasculopathies (FG)
GWS hits: 0

Survival analyses between endpoints


before Other necrotizing vasculopathies (FG)
after Other necrotizing vasculopathies (FG)

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Drugs most likely to be purchased after Other necrotizing vasculopathies (FG)