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Spondylopathies

DOIDEFOMESHSNOMED PheWeb

M13_SPONDYLOPATHY

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M45-M49
Cause of death: ICD-10 M45-M49

28295

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

28295

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Check minimum number of events None

28295

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Include endpoints

29964

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M13_SPONDYLOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 29143 15717 13426
Unadjusted prevalence (%) 9.45 9.06 9.94
Mean age at first event (years) 58.02 57.54 58.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.57 [1.40, 1.77] 6.1e-14 2877
15 years 0.01 1.06 [0.95, 1.18] 3.1e-1 1450
5 years 0.00 1.66 [1.48, 1.85] 7.2e-19 707
1 year 0.00 3.19 [2.71, 3.76] 8.8e-44 262

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOPATHY – Spondylopathies
GWS hits: 11

Survival analyses between endpoints

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Plot

before Spondylopathies
after Spondylopathies

loading spinner Loading survival analyses plot