Discitis, unspecified

M13_DISCITIS

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M46.4
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M46.4
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

309

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

309

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Check minimum number of events None

309

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Include endpoints None

309

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M13_DISCITIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M46
Name in latin Discitis non specificata

Summary Statistics

Key figures

All Female Male
Number of individuals 303 118 185
Unadjusted prevalence (%) 0.10 0.07 0.14
Mean age at first event (years) 63.23 63.01 63.36

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.37 [1.95, 9.78] 3.3e-4 36
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_DISCITIS – Discitis, unspecified
GWS hits: 1

Survival analyses between endpoints

Plot

before Discitis, unspecified
after Discitis, unspecified

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Drugs most likely to be purchased after Discitis, unspecified