discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M40-M54
Cause of death: ICD-10 M40-M54


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Dorsopathies based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 81766 47439 34327
Unadjusted prevalence (%) 26.50 27.34 25.42
Mean age at first event (years) 49.43 48.43 50.81


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.39 [1.26, 1.53] 5.2e-11 6721
15 years 0.01 0.96 [0.88, 1.05] 4.0e-1 3114
5 years 0.00 1.73 [1.59, 1.89] 2.6e-36 1537
1 year 0.00 3.65 [3.21, 4.15] 1.4e-87 621

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_DORSOPATHY – Dorsopathies
GWS hits: 10

Survival analyses between endpoints


before Dorsopathies
after Dorsopathies

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