Deforming dorsopathies

M13_DEFORMDORSO

scoliosis: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M40-M43
Cause of death: ICD-10 M40-M43

6844

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

6844

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Check minimum number of events None

6844

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M13_DEFORMDORSO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Deforming dorsopathies based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 7333 4904 2429
Unadjusted prevalence (%) 2.38 2.83 1.80
Mean age at first event (years) 48.25 48.05 48.66

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.58 [1.13, 2.21] 6.9e-3 316
15 years 0.01 0.96 [0.68, 1.35] 8.0e-1 144
5 years 0.00 1.87 [1.30, 2.69] 7.1e-4 92
1 year 0.00 2.97 [1.87, 4.72] 3.9e-6 28

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_DEFORMDORSO – Deforming dorsopathies
GWS hits: 0

Survival analyses between endpoints

Plot

before Deforming dorsopathies
after Deforming dorsopathies

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Drugs most likely to be purchased after Deforming dorsopathies