Spondylolisthesis/Spondylolysis

DOID EFO MESH SNOMED PheWeb

M13_SPONDYLOLISTHESIS

spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M43.0, M43.1

Hospital discharge: ICD-9 7384

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M43.0, M43.1

Cause of death: ICD-9 7384

Cause of death: ICD-8 $!$

4398

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4398

Check minimum number of events None

4398

Include endpoints None

4398

M13_SPONDYLOLISTHESIS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Spondylolisthesis/Spondylolysis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4305	2773	1532
Unadjusted prevalence (%)	1.40	1.60	1.13
Mean age at first event (years)	55.25	55.83	54.21

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.73 [0.93, 3.23]	8.3e-2	167
15 years	0.01	1.27 [0.78, 2.08]	3.4e-1	84
5 years	0.00	2.49 [1.62, 3.82]	3.3e-5	46
1 year	0.00	3.40 [1.79, 6.44]	1.8e-4	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Spondylolisthesis/Spondylolysis
after Spondylolisthesis/Spondylolysis

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Table

Loading survival analyses table

Drugs most likely to be purchased after Spondylolisthesis/Spondylolysis

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