Spondylolisthesis/Spondylolysis

DOID EFO MESH SNOMED PheWeb

M13_SPONDYLOLISTHESIS

spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M43.0, M43.1

Hospital discharge: ICD-9 7384

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M43.0, M43.1

Cause of death: ICD-9 7384

Cause of death: ICD-8 $!$

4398

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4398

Check minimum number of events None

4398

Include endpoints None

4398

M13_SPONDYLOLISTHESIS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Spondylolisthesis/Spondylolysis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

4305

2773

1532

Unadjusted prevalence (%)

1.40

1.60

1.13

Mean age at first event (years)

55.25

55.83

54.21

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.73 [0.93, 3.23]	8.3e-2	167
15 years	0.01	1.27 [0.78, 2.08]	3.4e-1	84
5 years	0.00	2.49 [1.62, 3.82]	3.3e-5	46
1 year	0.00	3.40 [1.79, 6.44]	1.8e-4	12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Spondylolisthesis/Spondylolysis
after Spondylolisthesis/Spondylolysis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Spondylolisthesis/Spondylolysis

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