Other intervertebral disc disorders

DOID EFO MESH SNOMED PheWeb

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M51

Hospital discharge: ICD-9 722

Hospital discharge: ICD-8 725

Hospital discharge: excluded ICD-9 7220|7224|7227|7228A

Hospital discharge: excluded ICD-8 7250

Cause of death: ICD-10 M51

Cause of death: ICD-9 722

Cause of death: ICD-8 725

Cause of death: excluded ICD-9 7220|7224|7227|7228A

Cause of death: excluded ICD-8 7250

30936

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

30392

Check minimum number of events None

30392

Include endpoints None

30392

M13_INTERVERTEB

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M50-M54

Name in latin Aliae morbositates discorum intervertebralium

Similar endpoints

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List of similar endpoints to Other intervertebral disc disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	29508	16675	12833
Unadjusted prevalence (%)	9.56	9.61	9.50
Mean age at first event (years)	49.72	49.33	50.22

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.20 [1.01, 1.43]	4.0e-2	1859
15 years	0.01	0.95 [0.81, 1.10]	4.7e-1	948
5 years	0.00	1.40 [1.19, 1.64]	2.9e-5	351
1 year	0.00	1.63 [1.25, 2.12]	2.9e-4	74

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders
GWS hits: 10

Survival analyses between endpoints

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Plot

before Other intervertebral disc disorders
after Other intervertebral disc disorders

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Table

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Drugs most likely to be purchased after Other intervertebral disc disorders

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