Other intervertebral disc disorders


lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 M51
Hospital discharge: ICD-9 722
Hospital discharge: ICD-8 725
Hospital discharge: excluded ICD-9 7220|7224|7227|7228A
Hospital discharge: excluded ICD-8 7250
Cause of death: ICD-10 M51
Cause of death: ICD-9 722
Cause of death: ICD-8 725
Cause of death: excluded ICD-9 7220|7224|7227|7228A
Cause of death: excluded ICD-8 7250


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Summary Statistics

Key figures

All Female Male
Number of individuals 29508 16675 12833
Unadjusted prevalence (%) 9.56 9.61 9.50
Mean age at first event (years) 49.72 49.33 50.22


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.20 [1.01, 1.43] 4.0e-2 1859
15 years 0.01 0.95 [0.81, 1.10] 4.7e-1 948
5 years 0.00 1.40 [1.19, 1.64] 2.9e-5 351
1 year 0.00 1.63 [1.25, 2.12] 2.9e-4 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders
GWS hits: 10

Survival analyses between endpoints


before Other intervertebral disc disorders
after Other intervertebral disc disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other intervertebral disc disorders