Ankylosing spondylitis

M13_ANKYLOSPON

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M45

Hospital discharge: ICD-9 7200

Hospital discharge: ICD-8 7124

Cause of death: ICD-10 M45

Cause of death: ICD-9 7200

Cause of death: ICD-8 7124

2405

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2336

Check minimum number of events None

2336

Include endpoints None

2336

M13_ANKYLOSPON

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M45-M49

Name in latin Spondylarthritis/spondylitis ancylopoetica

Similar endpoints

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List of similar endpoints to Ankylosing spondylitis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2252	1048	1204
Unadjusted prevalence (%)	0.73	0.60	0.89
Mean age at first event (years)	42.20	41.90	42.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.96 [1.11, 3.47]	2.1e-2	128
15 years	0.01	1.39 [0.86, 2.26]	1.8e-1	59
5 years	0.00	1.31 [0.71, 2.40]	3.8e-1	14
1 year	0.00	5.83 [2.98, 11.40]	2.5e-7	11

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ANKYLOSPON – Ankylosing spondylitis
GWS hits: 19

Survival analyses between endpoints

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Plot

before Ankylosing spondylitis
after Ankylosing spondylitis

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Table

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Drugs most likely to be purchased after Ankylosing spondylitis

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