Ankylosing spondylitis


ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M45
Hospital discharge: ICD-9 7200
Hospital discharge: ICD-8 7124
Cause of death: ICD-10 M45
Cause of death: ICD-9 7200
Cause of death: ICD-8 7124


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M45-M49
Name in latin Spondylarthritis/spondylitis ancylopoetica

Summary Statistics

Key figures

All Female Male
Number of individuals 2252 1048 1204
Unadjusted prevalence (%) 0.73 0.60 0.89
Mean age at first event (years) 42.20 41.90 42.46


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.96 [1.11, 3.47] 2.1e-2 128
15 years 0.01 1.39 [0.86, 2.26] 1.8e-1 59
5 years 0.00 1.31 [0.71, 2.40] 3.8e-1 14
1 year 0.00 5.83 [2.98, 11.40] 2.5e-7 11

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_ANKYLOSPON – Ankylosing spondylitis
GWS hits: 19

Survival analyses between endpoints


before Ankylosing spondylitis
after Ankylosing spondylitis

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Drugs most likely to be purchased after Ankylosing spondylitis