Ankylosing spondylitis, strict definition

M13_ANKYLOSPON_STRICT

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

321302

diagram downward connector
diagram bullet

Check conditions

M13_ANKYLOSPON_ICD10

2179

diagram downward connector
diagram bullet

Filter registries

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M45

1984

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

956

diagram downward connector

Check minimum number of events None

956

diagram downward connector

Include endpoints None

956

diagram downward connector
M13_ANKYLOSPON_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 923 423 500
Unadjusted prevalence (%) 0.30 0.24 0.37
Mean age at first event (years) 41.41 40.69 42.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.00 0.32 [0.06, 1.57] 1.6e-1 10
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_ANKYLOSPON_STRICT – Ankylosing spondylitis, strict definition
GWS hits: 17

Survival analyses between endpoints

Plot

before Ankylosing spondylitis, strict definition
after Ankylosing spondylitis, strict definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ankylosing spondylitis, strict definition