Osteopathies and chondropathies

M13_OSTEOCHONDRO

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99

Cause of death: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99

13018

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

13018

Check minimum number of events None

13018

Include endpoints

M13_OSTEOPOROSIS

M13_OSTEOMALACIA

M13_BONECONTINUITY

M13_BONEDENSOTH

M13_OSTEOMYELITIS

M13_OSTEONECROSIS

M13_PAGET

M13_OTHERBONE

14837

M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Osteopathies and chondropathies based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	14361	9070	5291
Unadjusted prevalence (%)	4.65	5.23	3.92
Mean age at first event (years)	52.38	54.37	48.96

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.21 [2.64, 3.91]	1.9e-31	1628
15 years	0.01	1.44 [1.20, 1.73]	9.5e-5	532
5 years	0.01	4.43 [3.77, 5.19]	5.9e-75	603
1 year	0.00	11.59 [9.73, 13.80]	<1e-100	346

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOCHONDRO – Osteopathies and chondropathies
GWS hits: 0

Survival analyses between endpoints

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Plot

before Osteopathies and chondropathies
after Osteopathies and chondropathies

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Table

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Drugs most likely to be purchased after Osteopathies and chondropathies

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