Osteopathies and chondropathies

M13_OSTEOCHONDRO

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99
Cause of death: ICD-10 M80-M94, M90.6*C40.99, M90.6*C41.99

13018

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

13018

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Check minimum number of events None

13018

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M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 14361 9070 5291
Unadjusted prevalence (%) 4.65 5.23 3.92
Mean age at first event (years) 52.38 54.37 48.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.21 [2.64, 3.91] 1.9e-31 1628
15 years 0.01 1.44 [1.20, 1.73] 9.5e-5 532
5 years 0.01 4.43 [3.77, 5.19] 5.9e-75 603
1 year 0.00 11.59 [9.73, 13.80] <1e-100 346

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_OSTEOCHONDRO – Osteopathies and chondropathies
GWS hits: 0

Survival analyses between endpoints

Plot

before Osteopathies and chondropathies
after Osteopathies and chondropathies

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Drugs most likely to be purchased after Osteopathies and chondropathies