Osteonecrosis

DOID EFO MESH SNOMED PheWeb

M13_OSTEONECROSIS

osteonecrosis: A none disease characterized by death of bone tissue due to a lack of blood supply.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M87

Hospital discharge: ICD-9 7334

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M87

Cause of death: ICD-9 7334

Cause of death: ICD-8 $!$

1010

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1010

Check minimum number of events None

1010

Include endpoints None

1010

M13_OSTEONECROSIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M86-M90

Name in latin Osteonecrosis

Similar endpoints

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List of similar endpoints to Osteonecrosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Osteonecrosis due to drugs

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	970	553	417
Unadjusted prevalence (%)	0.31	0.32	0.31
Mean age at first event (years)	58.12	58.32	57.86

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.59 [1.60, 8.07]	1.9e-3	82
15 years	0.01	1.65 [0.83, 3.27]	1.5e-1	26
5 years	0.01	5.05 [3.01, 8.50]	9.9e-10	31
1 year	0.00	12.88 [7.05, 23.51]	8.8e-17	17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEONECROSIS – Osteonecrosis
GWS hits: 0

Survival analyses between endpoints

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Plot

before Osteonecrosis
after Osteonecrosis

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Table

Loading survival analyses table

Drugs most likely to be purchased after Osteonecrosis

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