osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M80, M81, M82*
Hospital discharge: ICD-9 733[0-1]
Hospital discharge: ICD-8 7230|72391
Cause of death: ICD-10 M80, M81, M82*
Cause of death: ICD-9 733[0-1]
Cause of death: ICD-8 7230|72391


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Osteoporosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 5354 4119 1235
Unadjusted prevalence (%) 1.74 2.37 0.91
Mean age at first event (years) 66.33 67.10 63.77


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.85 [3.91, 6.03] 3.7e-46 927
15 years 0.01 1.67 [1.36, 2.07] 1.7e-6 274
5 years 0.01 5.13 [4.27, 6.16] 1.0e-68 404
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 1

Survival analyses between endpoints


before Osteoporosis
after Osteoporosis

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