Osteoporosis

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M80, M81, M82*

Hospital discharge: ICD-9 733[0-1]

Hospital discharge: ICD-8 7230|72391

Cause of death: ICD-10 M80, M81, M82*

Cause of death: ICD-9 733[0-1]

Cause of death: ICD-8 7230|72391

5619

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5511

Check minimum number of events None

5511

Include endpoints None

5511

M13_OSTEOPOROSIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Osteoporosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5354	4119	1235
Unadjusted prevalence (%)	1.74	2.37	0.91
Mean age at first event (years)	66.33	67.10	63.77

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.85 [3.91, 6.03]	3.7e-46	927
15 years	0.01	1.67 [1.36, 2.07]	1.7e-6	274
5 years	0.01	5.13 [4.27, 6.16]	1.0e-68	404
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Osteoporosis
after Osteoporosis

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Table

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Drugs most likely to be purchased after Osteoporosis

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