Paget disease

M13_PAGET

osteitis deformans: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M88

Hospital discharge: ICD-9 7310

Hospital discharge: ICD-8 72199

Cause of death: ICD-10 M88

Cause of death: ICD-9 7310

Cause of death: ICD-8 72199

2149

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

M13_PAGET

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M86-M90

Name in latin Osteitis deformans Paget

Similar endpoints

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List of similar endpoints to Paget disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	87	41	46
Unadjusted prevalence (%)	0.03	0.02	0.03
Mean age at first event (years)	63.16	62.34	63.89

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_PAGET – Paget disease
GWS hits:

Survival analyses between endpoints

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Plot

before Paget disease
after Paget disease

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Table

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Drugs most likely to be purchased after Paget disease

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