Otherdisorders of bone

M13_OTHERBONE

secondary hypertrophic osteoarthropathy: Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94

Cause of death: ICD-10 M89, M90*, M90.6*C40.99, M90.6*C41.99, M91-M94

3721

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

3721

Check minimum number of events None

3721

Include endpoints

M13_ALGONEURO

M13_EPIPHYARR

M13_BONEDEV

M13_BONEHYPERTRPH

M13_HYPERTRPHOSTEOARTHR

M13_OSTEOLYSIS

M13_OSTEOPATHYPOSTPOLIO

M13_BONEDISNAS

M13_OSTEOPATHYINOTH

M13_CHRONDROPATHIES

5250

M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Otherdisorders of bone based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5079	2946	2133
Unadjusted prevalence (%)	1.65	1.70	1.58
Mean age at first event (years)	38.71	40.05	36.85

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.46 [0.96, 2.24]	7.8e-2	286
15 years	0.01	0.86 [0.59, 1.25]	4.2e-1	104
5 years	0.00	2.02 [1.42, 2.86]	8.9e-5	60
1 year	0.00	7.68 [5.30, 11.14]	6.0e-27	44

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OTHERBONE – Otherdisorders of bone
GWS hits: 0

Survival analyses between endpoints

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Plot

before Otherdisorders of bone
after Otherdisorders of bone

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Table

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Drugs most likely to be purchased after Otherdisorders of bone

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