Asthma

J10_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J45, J46

Hospital discharge: ICD-9 493

Hospital discharge: ICD-8 493

Cause of death: ICD-10 J45, J46

Cause of death: ICD-9 493

Cause of death: ICD-8 493

33507

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

33502

Check minimum number of events None

33502

Include endpoints None

33502

J10_ASTHMA

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Asthma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	32351	19875	12476
Unadjusted prevalence (%)	10.48	11.45	9.24
Mean age at first event (years)	44.81	43.55	46.82

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.98 [1.71, 2.29]	9.9e-20	3147
15 years	0.01	1.31 [1.15, 1.50]	7.2e-5	1437
5 years	0.00	2.41 [2.13, 2.71]	1.5e-46	805
1 year	0.00	5.40 [4.62, 6.31]	1.8e-99	353

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_ASTHMA – Asthma
GWS hits: 27

Survival analyses between endpoints

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Plot

before Asthma
after Asthma

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Table

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Drugs most likely to be purchased after Asthma

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