Chronic lower respiratory diseases

DOID EFO MESH SNOMED PheWeb

J10_LOWCHRON

lung disease: A disease involving the lung.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J40-J47

Cause of death: ICD-10 J40-J47

40220

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

40220

Check minimum number of events None

40220

Include endpoints

J10_BRONCH

J10_SIMPLBRONCH

J10_BRONCHNAS

J10_COPD

J10_ASTHMA

J10_BRONCHIECTASIS

J10_ASTHMACOPDKELA

51665

J10_LOWCHRON

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Chronic lower respiratory diseases based on the number of shared cases.

Broader endpoints:

Diseases of the respiratory system

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	50026	27291	22735
Unadjusted prevalence (%)	16.21	15.73	16.84
Mean age at first event (years)	47.24	43.67	51.54

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.63 [2.36, 2.93]	3.9e-69	7261
15 years	0.01	1.62 [1.47, 1.79]	8.2e-23	2902
5 years	0.00	3.51 [3.23, 3.82]	<1e-100	2035
1 year	0.00	10.73 [9.55, 12.05]	<1e-100	1299

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_LOWCHRON – Chronic lower respiratory diseases
GWS hits: 35

Survival analyses between endpoints

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Plot

before Chronic lower respiratory diseases
after Chronic lower respiratory diseases

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Table

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Drugs most likely to be purchased after Chronic lower respiratory diseases

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