Asthma, hospital admissions , main diagnosis only

ASTHMA_HOSPITAL_MAIN

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J45, J46

Hospital discharge: ICD-9 493

Hospital discharge: ICD-8 493

33461

Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked

Look only at ICD versions H.D: 10, 8, 9

27293

Check minimum number of events None

27293

Include endpoints None

27293

ASTHMA_HOSPITAL_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Asthma, hospital admissions , main diagnosis only based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	26358	16385	9973
Unadjusted prevalence (%)	8.54	9.44	7.39
Mean age at first event (years)	42.21	41.29	43.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.83 [1.58, 2.11]	2.5e-16	2312
15 years	0.01	1.29 [1.13, 1.47]	2.0e-4	1123
5 years	0.00	2.19 [1.93, 2.48]	1.9e-34	536
1 year	0.00	3.27 [2.69, 3.97]	4.6e-33	154

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ASTHMA_HOSPITAL_MAIN – Asthma, hospital admissions , main diagnosis only
GWS hits: 21

Survival analyses between endpoints

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Plot

before Asthma, hospital admissions , main diagnosis only
after Asthma, hospital admissions , main diagnosis only

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Table

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Drugs most likely to be purchased after Asthma, hospital admissions , main diagnosis only

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