Asthma (only as main-diagnosis)

J10_ASTHMA_MAIN

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J45, J46

Hospital discharge: ICD-9 493

Hospital discharge: ICD-8 493

Cause of death: ICD-10 J45, J46

Cause of death: ICD-9 493

Cause of death: ICD-8 493

33507

Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

27298

Check minimum number of events None

27298

Include endpoints None

27298

J10_ASTHMA_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Asthma (only as main-diagnosis) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

26363

16387

9976

Unadjusted prevalence (%)

8.54

9.44

7.39

Mean age at first event (years)

42.22

41.30

43.73

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.71 [1.46, 2.01]	3.2e-11	2317
15 years	0.01	1.23 [1.07, 1.41]	4.0e-3	1123
5 years	0.00	2.01 [1.75, 2.33]	1.0e-21	536
1 year	0.00	3.13 [2.56, 3.83]	1.6e-28	159

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_ASTHMA_MAIN – Asthma (only as main-diagnosis)
GWS hits: 27

Survival analyses between endpoints

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Plot

before Asthma (only as main-diagnosis)
after Asthma (only as main-diagnosis)

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Table

Loading survival analyses table

Drugs most likely to be purchased after Asthma (only as main-diagnosis)

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