Asthma, unspecified (mode)

ASTHMA_NAS

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 J45.9
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 J45.9
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

30214

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Check pre-conditions, main-only, mode, ICD version

Check mode of ICD-10 codes: %J459
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

16601

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Check minimum number of events None

16601

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Include endpoints None

16601

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ASTHMA_NAS

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 20883 13055 7828
Unadjusted prevalence (%) 6.77 7.52 5.80
Mean age at first event (years) 53.63 51.67 56.89

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 3.08 [2.45, 3.88] 6.4e-22 2315
15 years 0.01 1.67 [1.40, 2.00] 2.1e-8 948
5 years 0.00 3.70 [3.24, 4.23] 1.1e-82 761
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ASTHMA_NAS – Asthma, unspecified (mode)
GWS hits: 6

Survival analyses between endpoints

Plot

before Asthma, unspecified (mode)
after Asthma, unspecified (mode)

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Drugs most likely to be purchased after Asthma, unspecified (mode)