Other degenerative diseases of the nervous system

G6_NEURODEG

neurodegenerative disease: A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

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G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Other degenerative diseases of the nervous system based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 7288 3173 4115
Unadjusted prevalence (%) 2.36 1.83 3.05
Mean age at first event (years) 76.53 77.34 75.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 8.72 [7.10, 10.71] 4.0e-95 3587
15 years 0.02 2.53 [2.06, 3.10] 5.0e-19 894
5 years 0.01 6.66 [5.87, 7.56] <1e-100 1563
1 year 0.00 16.96 [14.94, 19.27] <1e-100 1106

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_NEURODEG – Other degenerative diseases of the nervous system
GWS hits: 2

Survival analyses between endpoints

Plot

before Other degenerative diseases of the nervous system
after Other degenerative diseases of the nervous system

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Drugs most likely to be purchased after Other degenerative diseases of the nervous system