Alzheimer disease

G6_ALZHEIMER

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G30

Hospital discharge: ICD-9 3310

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 G30

Cause of death: ICD-9 3310

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

6508

G6_ALZHEIMER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G30-G32

Name in latin Morbus Alzheimer

Similar endpoints

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List of similar endpoints to Alzheimer disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Alzheimer’s disease (undefined)

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6281	2853	3428
Unadjusted prevalence (%)	2.04	1.64	2.54
Mean age at first event (years)	79.16	79.39	78.97

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	7.11 [5.21, 9.69]	2.6e-35	3257
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Alzheimer disease
after Alzheimer disease

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Table

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Drugs most likely to be purchased after Alzheimer disease

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