Alzheimer’s disease, wide definition

G6_AD_WIDE

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00*, G30

Hospital discharge: ICD-9 3310

Hospital discharge: ICD-8 29010

Cause of death: ICD-10 F00*, G30

Cause of death: ICD-9 3310

Cause of death: ICD-8 29010

KELA reimbursements: KELA codes 307

KELA reimbursements: ICD-10 F00*, G30

Medicine purchases: ATC N06D

10261

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

9592

Check minimum number of events

Min. number of events 3

9592

Include endpoints

F5_ALZHDEMENT

9592

G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Alzheimer’s disease, wide definition based on the number of shared cases.

Broader endpoints:

None

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	9271	4187	5084
Unadjusted prevalence (%)	3.00	2.41	3.77
Mean age at first event (years)	78.04	78.38	77.76

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	6.61 [5.65, 7.74]	<1e-100	3771
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 3

Survival analyses between endpoints

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Plot

before Alzheimer’s disease, wide definition
after Alzheimer’s disease, wide definition

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease, wide definition

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