Alzheimer’s disease (Late onset)

AD_LO

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

4446

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4446

Check minimum number of events None

4446

Include endpoints None

4446

AD_LO

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alzheimer’s disease (Late onset) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4282	1984	2298
Unadjusted prevalence (%)	1.39	1.14	1.70
Mean age at first event (years)	79.76	80.12	79.44

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.11	7.79 [5.58, 10.89]	2.3e-33	2260
15 years	0.02	2.22 [1.60, 3.06]	1.4e-6	577
5 years	0.01	6.02 [5.10, 7.11]	9.0e-100	964
1 year	0.00	16.52 [14.12, 19.32]	<1e-100	713

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AD_LO – Alzheimer’s disease (Late onset)
GWS hits: 2

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Late onset)
after Alzheimer’s disease (Late onset)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Alzheimer’s disease (Late onset)

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