Any mental disorder

KRA_PSY_ANYMENTAL

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F0[0-3]|F051|G30|F[1-9]

Hospital discharge: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A

Hospital discharge: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

Cause of death: ICD-10 F0[0-3]|F051|G30|F[1-9]

Cause of death: ICD-9 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A

Cause of death: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

78940

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

78804

Check minimum number of events None

78804

Include endpoints

KRA_PSY_DEMENTIA

VWXY20_SUICI_OTHER_INTENTI_SELF_H

79111

KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Any mental disorder based on the number of shared cases.

Broader endpoints:

Any ICDMAIN event in hilmo or causes of death

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

76073

43307

32766

Unadjusted prevalence (%)

24.66

24.96

24.27

Mean age at first event (years)

42.90

41.00

45.42

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	4.25 [3.86, 4.67]	<1e-100	10271
15 years	0.01	2.27 [2.05, 2.50]	1.3e-57	3419
5 years	0.00	5.13 [4.74, 5.56]	<1e-100	3174
1 year	0.00	16.36 [14.67, 18.25]	<1e-100	2445

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder
GWS hits: 9

Survival analyses between endpoints

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Plot

before Any mental disorder
after Any mental disorder

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Any mental disorder

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