Any mental disorder

KRA_PSY_ANYMENTAL

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 F0[0-3]|F051|G30|F[1-9]
Hospital discharge: ICD-9  29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A 
Hospital discharge: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310
Cause of death: ICD-10 F0[0-3]|F051|G30|F[1-9]
Cause of death: ICD-9  29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A 
Cause of death: ICD-8 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

78940

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

78804

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Check minimum number of events None

78804

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KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 76073 43307 32766
Unadjusted prevalence (%) 24.66 24.96 24.27
Mean age at first event (years) 42.90 41.00 45.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 4.25 [3.86, 4.67] <1e-100 10271
15 years 0.01 2.27 [2.05, 2.50] 1.3e-57 3419
5 years 0.00 5.13 [4.74, 5.56] <1e-100 3174
1 year 0.00 16.36 [14.67, 18.25] <1e-100 2445

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder
GWS hits: 9

Survival analyses between endpoints

Plot

before Any mental disorder
after Any mental disorder

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Drugs most likely to be purchased after Any mental disorder