Other and unspecified degenerative diseases of nervous system

G6_DEGENOTH

Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G31.8, G31.9, G32*

Hospital discharge: ICD-9 331[8-9]

Hospital discharge: ICD-8 32303

Cause of death: ICD-10 G31.8, G31.9, G32*

Cause of death: ICD-9 331[8-9]

Cause of death: ICD-8 32303

415

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

405

Check minimum number of events None

405

Include endpoints None

405

G6_DEGENOTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other and unspecified degenerative diseases of nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	392	153	239
Unadjusted prevalence (%)	0.13	0.09	0.18
Mean age at first event (years)	65.48	62.16	67.60

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other and unspecified degenerative diseases of nervous system
after Other and unspecified degenerative diseases of nervous system

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Table

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Drugs most likely to be purchased after Other and unspecified degenerative diseases of nervous system

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