Hyperfunction of pituitary gland


hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10


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Check minimum number of events None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

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Summary Statistics

Key figures

All Female Male
Number of individuals 1166 895 271
Unadjusted prevalence (%) 0.38 0.52 0.20
Mean age at first event (years) 38.51 36.07 46.58


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.91 [1.06, 3.45] 3.2e-2 52
15 years 0.01 1.10 [0.60, 2.02] 7.6e-1 20
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: 0

Survival analyses between endpoints


before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland