Other endocrine disorders

DOID EFO MESH SNOMED PheWeb

E4_ENDODIS

endocrine system disease: A disease involving the endocrine system.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E34, E35

Cause of death: ICD-10 E34, E35

1253

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1239

Check minimum number of events None

1239

Include endpoints

E4_CARCISDR

E4_HYPERSEC

E4_ECTHOR

E4_SHORT

E4_TALL

E4_ANDRORESIST

E4_ENDODISNAS

E4_ENDINOTH

1315

E4_ENDODIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other endocrine disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1246	732	514
Unadjusted prevalence (%)	0.40	0.42	0.38
Mean age at first event (years)	30.51	29.85	31.44

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	5.34 [3.22, 8.87]	9.5e-11	66
15 years	0.02	2.52 [1.43, 4.44]	1.4e-3	29
5 years	0.00	3.98 [2.06, 7.67]	3.7e-5	23
1 year	0.00	8.14 [3.72, 17.85]	1.6e-7	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ENDODIS – Other endocrine disorders
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other endocrine disorders
after Other endocrine disorders

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Table

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Drugs most likely to be purchased after Other endocrine disorders

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